Acupuncture for the Treatment of Gastro-Oesophageal Reflux Disease: A Systematic Review and Meta-Analysis
https://doi.org/10.1136/acupmed-2016-011205
Article Information
Volume: 35 issue: 5, page(s): 316-323
Article first published online: December 12, 2018; Issue published: October 1, 2017
Jiajie Zhu, , Yu Guo, Shan Liu, Xiaolan Su, Yijie Li, Yang Yang, Liwei Hou, Guishu Wang, Jiaxin Zhang, Jiande JD Chen, Qingguo Wang, Ruhan Wei, Wei Wei
1Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
2Department of Gastroenterology, Beijing Key Laboratory of Functional Gastrointestinal Disorders Diagnosis and Treatment of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
3Basic Medical College, Beijing University of Chinese Medicine, Beijing, China
4Division of Gastroenterology and Hepatology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
5Cleveland State University, Cleveland, Ohio, USA
Corresponding Author:
Professor Wei Wei, Beijing Key Laboratory of Functional Gastrointestinal Disorders Diagnosis and Treatment of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6 Wangjing Zhonghuan Road, Chaoyang District, Beijing 100102, China; sxxtyy@sina.com
Abstract
Background: Gastro-oesophageal reflux disease (GORD) is one of the most common diseases presenting to gastroenterology clinics. Acupuncture is widely used as a complementary and alternative treatment for patients with GORD.
Objective: To explore the effectiveness of acupuncture for the treatment of GORD.
Methods: Four English and four Chinese databases were searched through June 2016. Randomised controlled trials investigating the effectiveness of manual acupuncture or electroacupuncture (MA/EA) for GORD versus or as an adjunct to Western medicine (WM) were selected. Data extraction and quality evaluation were performed by two authors independently and RevMan 5.2.0 was used to analyse data.
Results: A total of 12 trials involving 1235 patients were included. Meta-analyses demonstrated that patients receiving MA/EA combined with WM had a superior global symptom improvement compared with those receiving WM alone (relative risk (RR) 1.17, 95% CI 1.09 to 1.26; p=0.03; six studies) with no significant heterogeneity (I2=0%, p=0.41). Recurrence rates of those receiving MA/EA alone were lower than those receiving WM (RR 0.42,95% CI 0.29 to 0.61; p<0.001; three studies) with low heterogeneity (I2=7%, p=0.34), while global symptom improvement (six studies) and symptom scores (three studies) were similar (both p>0.05). Descriptive analyses suggested that acupuncture also improves quality of life in patients with GORD.
Conclusion: This meta-analysis suggests that acupuncture is an effective and safe treatment for GORD. However, due to the small sample size and poor methodological quality of the included trials, further studies are required to validate our conclusions.